Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
SARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다
Research Article
[키워드] ACE2
ACE2 receptor
activate
activated
acute respiratory syndrome coronavirus
Amino acid
Antiviral
antiviral therapies
attachment
binding
Cell
cell-cell fusion
cells
cellular protease
cellular proteases
cleavage
cleaved
cocktail
coronavirus
COVID-19 pandemic
CRISPR
CRISPR-Cas9
Donor
drug
focus
furin
furin cleavage
furin inhibitor
furin inhibitors
furin knockout cell
furin knockout cells
furin protease
fusion
fusion peptide
host cell
host cell membrane
host cell receptor
infect
infected cell
Infection
inhibitor
inhibitors
motif
multibasic site
multinucleated cells
mutant
Mutation
peptide
pre-activation
Prevent
promote
protease
protease TMPRSS2
Protein
reduce
reduces
required
Research
respiratory
responsible
reveal
S protein
S-mediated cell-cell fusion
SARS-CoV-2
SARS-CoV-2 antiviral therapy
SARS-COV-2 infection
SARS-CoV-2 infections
SARS-CoV-2 S
SARS-CoV-2 S protein
SARS-CoV-2 virus
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
spike
Spread
syncytia formation
target cell
the S protein
the SARS-CoV-2
thought
TMPRSS2
TMPRSS2 protease
treat
triggered
triggering
unique
Viral
viral infection
Viral protein
viral spread
virus
virus entry
virus entry process
virus-host membrane fusion
[DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article